مقالات

Evaluation of survival and related factors in cirrhotic patients in Kurdistan province

1398/5/24 10:48
مقدمه

Liver cirrhosis is the final stage of chronic liver disease that disrupts the normal functioning of the liver, causing various complications in the patient. The aim of this study was to estimate the survival rate in patients with liver cirrhosis using MELD and Child-pugh scoring methods and its related factors on liver cirrhosis survival in Kurdistan province.

روش کار

In this retrospective cohort study, all subjects with diagnosed liver cirrhosis referred to digestive and liver ward of Tohid Hospital in Sanandaj in Kurdistan province in 2011-2017 were evaluated. To analyze survival rate, Kaplan-Meier method and log-rank test and univariate regression and hazard ratio calculation were performed using Cox relative risk model. .

نتایج

In this study, 187 people with liver cirrhosis were studied, The mean (standard deviation) age was 56.1 (17.6) years, of which 115 (61.5%) were male, 90 (48.1%) were over 60 years, and 37 (17.8% ) Were less than 40 years old. In this study, 85 (45.5%) had died, the cause of death in 48 patients (57.8%) is liver cirrhosis were reported. Survival rates of patients with cirrhosis were 1, 3 and 5 years, respectively, 94.3%, 66.7%, 41%, and median survival was 52 months. Univariate regression analysis showed that individuals younger than 40 years of age had higher mortality (HR 2.10, 95% CI 1.26-3.50, P = 0.004) But in the age group of 40-59 years, there was no significant difference (P = 0.178). In patients with liver cirrhosis, patients with Child pugh had stage B (HR 1.19, 95% CI 0.78-1.81, P = 0.397) and stage C (HR 1.27, 95% CI 0.65-2.48, P = 0.482).

نتیجه‌گیری

Due to the high mortality risk and severity of the disease at an early age, it requires the diagnosis of liver cirrhosis, rapid follow-up of patients, further interventions and the development of a diagnostic surveillance system.