Introduction: functional dyspepsia (FD), is one of the most prevalent functional gastrointestinal disorders, associated with a serious disturbance in the quality of life of patients. Several studies reported the efficacy of herbal materials in improvement of FD symptoms. We aimed to evaluate a common, and famous herbal remedy of Zireh in clinical symptom of FD

40 patients 20 to 60 years old with FD (based on the Rome IV criteria), were enrolled to this double-blind randomized controlled clinical trial, with parallel groups allocation ratio of 1:1, mentally alert, and able to answer the questions; those with complications during intervention, pregnancy, lactation, and severe organic or psychiatric disorders were excluded. All participants received one 500 mg capsule contained herbal remedy (Zireh), or corn starch (placebo), three times a day, after meal, for 4 weeks. Severity, and frequency of symptoms were evaluated through Stangellini, and Rome IV questionnaires at baseline, after 2, 4, and 8 weeks. Chi-square test, Levene ‘s test, and t-test were used to statistical analysis. This study was registered in Iranian Registry of clinical trial (IRCT20210602051471N1)

There were no significant differences in demographic data, symptom severity, and symptoms frequency between groups at baseline. Total symptoms severity score was improved significantly (P= 0.02), as well as early satiety (P= 0.003), epigastric pain (P=0.023), bloating (P= 0.008), epigastric burning (P<0.001), and nausea (P= 0.003). no significant differences were observed in terms of symptoms frequency, as well as vomiting, belching, fullness.

this herbal remedy can alleviate the symptoms severity in patients with FD. It is recommended to continue recruiting participants with FD until a sufficient sample size is reached.