Coronavirus infection (COVID-19) is caused by novel coronavirus SARS-CoV-2, which has affected more that 160 million people around the world. Manifestations of this infection vary widely among patients but the most common presentation is respiratory symptoms. liver enzymes abnormalities is one of the reported presentations mostly in hospitalized patients.

Patient report: a 39-year-old man who has been recently tested positive for COVID-19, presented with jaundice. liver enzyme patterns showed acute severe hepatitis. Although liver enzymes changes is a quiet common manifestation in COVID-19 infection, further investigation was done to rule out any other possible cause of acute severe hepatitis. Hepatitis A antibody IgM and herpes simplex virus antibody IgM came back positive. With conservative and symptomatic management, liver function tests and coagulation studies were back to normal values within only 2 months of symptoms presentation.

Conclusion: We hereby reported case of a patient who was infected with three viruses at the same time. In our patient, COVID 19 infection on one hand and simultaneous HAV and HSV infections on the other hand, aggravated liver function which led to severe acute hepatitis. In conclusion, physicians should take all the possible causes of acute hepatitis in consideration when dealing with abnormal liver enzymes in a patient with COVID-19 infection.