Curcumin is a key polyphenolic yellow pigment found in turmeric root, which includes it’s anti-oxidant, anti-inflammatory and anti-microbial properties and has been proved to be effective in inhibition of H.pylori infection, in vitro. Therefore we aim to investigate whether addition of Curcumin to the standard triple therapy will increase the eradication rate of H.pylori infection.

In this randomized double-blind, placebo-controlled, patients that will undergo esophagogastroscopy and will be positive for H.pylori according to Rapid urease test were assigned to standard H. pylori eradication triple therapy with clarithromycin, amoxicillin and pantoprazole, and randomized to receive either curcumin (500 mg/day) or placebo as adjunct to standard treatment. Eradication of H. pylori infection was assessed using the urea breath test (UBT) at 8 weeks following the end of treatment.

the results of UBT test showed Eradication Rate of Helicobacter pylori was 68% and 65% in the curcumin and placebo groups, respectively and there was no significant difference between two groups.

Addition of curcumin on top of the standard anti-helicobacter regimen is safe but has no enhancing effect on the eradication of H. pylori infection.