Introduction: Epidemiological researchers have demonstrated that colorectal cancer (CRC) is the third common cancer in the world, and it is the second leading cause of cancer mortality in developed countries. Heavy metals such as cadmium (Cd) have a prognostic role in cancers especially in CRC. Cd induces formation of reactive oxygen species (ROS), which in turn cause damage to DNA and interfere with cellular signaling. Natural components such as Frankincense resin have recently gained attention for their anti-cancer and chemopreventive properties. This review discusses the anti-carcinogenicity effects of Frankincense resin on Cd toxicity. Materials The electronic database between 2000-2021 were searched using the search terms "frankincense", "cadmium", "oxidative stress", and "colorectal cancer". Only articles published in English have been included. Combination treatments of frankincense with other herbal products were excluded. Results: Cadmium as a type I carcinogen increases the risk of cancers especially CRC. In vitro studies on CRC cell lines (RKO and HT-29 cell lines) showed that Cd induces oxidative stress, inflammation and metastasis in CRC cell lines. Cd could represent its carcinogenicity by oxidative stress products such as ROS through destruction of antioxidant defense and DNA repair systems, impairment of protein activity, activation of lipid peroxidation, and chromosomal aberrations, and induction of apoptosis pathways. FRN is an aromatic resin with antioxidant, anti-inflammatory, anti-cancer, and anti-proliferative properties. In vitro studies showed that FRN could inhibit the growth of CRC cells. In addition, several clinical studies showed the anti-inflammatory and anti-tumor activities of FRN. FRN and Boswellia properties are related to their compositions such as boswellic acids, saponins, alkaloids, polyphenols, essential oils, and polysaccharides. FRN could reduce ROS, reactive nitrogen species (RNS), and membrane lipid peroxidation; and simultaneously could inhibit inflammation by inhibition of nuclear factor kappa-B (NFĸB) which mediates production of inflammatory cytokines/chemokine's (Tumor necrosis factor α, Interferon-gamma, Interleukin 1(IL 1), IL 2, IL4, and IL6. Moreover, FRN can induce apoptosis by reduction of mitochondrial membrane potential, B-cell lymphoma 2 protein, BCL extra-large protein, inhibition of apoptotic protein, and activation of caspases 3, 8, and 9. Conclusion: Antioxidant, anticancer, and anti-inflammatory properties of frankincense and Boswellia could be used in cancer chemoprevention in combination with conventional treatments.