Helicobacter pylori, a microaerophilic Gram-negative bacterium, is the most common chronic gastric bacterial infection that caused gastritis and gastric ulcer and increase the risk of gastric cancer. The estimated prevalence of H. pylori is 70% in developing countries and 30-40% in developed countries. Evaluation and treatment of H. Pylori is recommended in all patients with dyspepsia and also should be considered in Family history of gastric cancer. Despite numerous treatment regimen, overuse or misuse of antibiotics lead to increase resistance to antibiotics. Also, the administration of long term antibiotics produces many adverse effects. Several studies show the effects of herbal medicine on H. pylori eradication. The aim of this systematic review is to evaluate the efficacy of Persian herbal medicine in the treatment of H. pylori infection.

In this article, electronic databases including Pubmed, Scopus, Cochrain, Embase, Web of science and SID were searched to find clinical articles related to H. pylori infection from 1966 to 2019. We used the following search strategy: "Traditional medicine" or "Complementary and Alternative medicine" or "herb" or "plant" and "H. pylori". None randomized clinical trial, none relevant studies, supplement, vitamins, pre or probiotics and none Persian herbal drugs were excluded.

We found 8 double blind randomized clinical trial articles. Many Persian herbal medicine such Berberis vulgaris, Mentha piperata, Curcuma longa, Nigella sativa, Glycyrrhiza glabra, Piastacia atlantica, Mastic gum and mix preparation of Carum carvi and Mentha piparata have anti-H. pylori activity and improve gastroduodenal symptoms.

Athough, the mechanism of herbal medicine on H. pylori not fully understood, Several studies explored that addition of herbal medicine to the standard H. pylori regimen, raise the ulcer healing and H. Pylori eradication rate.