CRC going to be an important issue in Middle East countries. Also the main parts of this cancer develop from benign adenomas. To understanding 5-year recurrence rate of colorectal polyp among average risk subjects.

In a prospective study the average-risk patients with colorectal adenoma were enrolled in this study based on inclusion criteria. The patients were consulted annually by an expert gastroenterologist. A control colonoscopy was programmed after three years of follow-up. It was not an obligation to follow our program and each patient could exit from the study at any time. The patient who develops one of the exclusion criteria was also withdrawn of study by the gastroenterologist of this study.

237 patients were enrolled in this study. Of them 102 patients completed 5-year follow-up. Among these participants, 62 (60.8%) were male and 40 (39.2%) were female, with a mean age of 57.05 ± 12.87 years. Additionally, 20 (19.6%) subjects had adenomatous polyps at end of study. The polyps raised in patients with large size , tubulovillous and tubular types polyps. The polyps more localized in sigmoid following descending and transverse colon. Furthermore , High grade dysplasia recorded in 5 patients that one of them show in situ cancer.

We believed that the colonoscopy screening need to set up in regions that previously considered as low- risk region for CRC. Also, in patients with high grade dysplasia it may valuable that control colonoscopy less than three years.