مقالات

Prevalence of nonalcoholic fatty liver disease in kidney transplantation candidates

1398/4/30 18:29
مقدمه

Background: There are few published articles about the prevalence of nonalcoholic fatty liver disease (NAFLD) in kidney transplantation candidates. The recent researches suggest a possible association between NAFLD and chronic kidney disease.

روش کار

Methods: Sonographic findings of consecutive candidate patients for renal transplantation were evaluated for detection of NAFLD. The different types of NAFLD were categorized based on severity of NAFLD in solography (grade 1 to 3) and were also compared with each other. Comparisons between the groups were analyzed by the chi-square test for categorical variables. P values < 0.05 were considered statistically significant. Statistical analyses were performed with SPSS Version 25.

نتایج

Results: 291 (111 female and 180 male) kidney transplantation candidates were conducted in this study. The mean age (SD; minimum; maximum) of patients was 47.33 (14.152; 18; 81) years. The ethnicities of patients (N ;%) were Fars (230; 79.04%), Lurs (53; 18.21%), Baloch (6; 2.06%), and Azerbaijanis (2; 0.69%). 206 (70.8%) of patients did not have NAFLD and 85 (29.2%) had NAFLD. The mean age (SD) of patients with and without NAFLD were 55.57 (16.79%) and 42.65 (17.12%) years, respectively. Grade 1and 2 of NAFLD were detected in 81 and 4 patients with NAFLD, respectively. There was not any patient with grade 3 fatty liver. There was not any significant relationship in the prevalence of NAFLD between two different sex groups (p=0 .342).

نتیجه‌گیری

Conclusions: Based on our results the prevalence of in NAFLD is considerable in kidney transplantation candidates, so management of fatty liver and related risk factor may be useful in these patients. On the other hand, the severe type of NAFLD was not seen in this population. Because of several limitation of our study, we propose well designed studies to detection of possible correlation.