This study attempts to investigate serum levels. In patients with and without Helicobacter pylori infection, ATG5 further elucidates the role of autophagy in this disease.

The present study is a case-control study. In this study individuals aged 35-50 years who undergo endoscopy, were referred to Razi Medical Center in 1397 and studied for Helicobacter pylori infection. The subjects were divided into two groups: Helicobacter pylori infection and non-Patients. Detection criteria for Helicobacter pylori infection in the first step were Test Ureas Rapid (made by Pars Biocomputer Company) and then the pathology result. People who are both positive were considered as the case group and other subjects as the control group.

The present study was performed on 44 patients (22 Helicobacter pylori positive and 22 negatives). Of these, 56.8% were male. 77.3% were over 40 years old, 70.5% (1-12%) were literate. 52.3% BMI was less than 25 and 70.5% were a non-smoker. Statistical analysis results showed that there is no significant difference between positive and negative Helicobacter pylori based on ATG number 5. P = 0.222) and serum concentration of autophagy protein 5 in patients with and without Helicobacter pylori infection only among men and women. There was a significant difference between the two groups (66.2%) and more than men (55.8%).

In this study, there was no significant difference between the two groups (with and without Helicobacter pylori infection) in Autophagy No. 5