IntroductionIntroduction Colorectal cancer (CRC) rates increased dramatically significantly over the last few decades. Oxidative stress have been proposed as major factors in the pathogenesis of this cancer, which can cause by exposure to toxic heavy metals, such as lead (Pb). Recently gained attention to natural anti-oxidant fruits such as oleaster (Ziziphus Jujuba), for modulation of induced oxidative stress by Pb. This review aims to highlight the antioxidant and free radical scavenging properties of jujube fruit for the decrease of induced oxidative stress by Pb. Methods Ziziphus Jujuba Mill, lead, Pb, colorectal cancer were researched in electronic English databases (between 2000 and 2021) and relevant English published articles were included. Results: Relevant studies showed that high level of Pb may exert diverse toxic effects on colorectal cells. Pb’s toxicity could induce oxidative stress and alter antioxidant activities by inhibiting functional SH groups in antioxidant enzymes. Oxidative stress products could directly or indirectly increase lipid peroxidation, DNA and proteins damages, defects DNA repair, surpasses the antioxidant levels, alter regulations of genes, signal transduction and cell growth. In vitro and in vitvo studies have been reported that Pb can promote tumorigenesis, metastasis and angiogenesis (by inducing interleukin-8 expression); activate epidermal growth factor receptor and induces phosphorylation of downstream extracellular signal-regulated kinase (ERK)-1/2; and increase lipid peroxidation or decrease antioxidant defense mechanism. Nowadays, Ziziphus Jujuba is attended as a medicinal herb with antioxidant, anticancer, anti-inflammatory activities. In vitro and in vitvo studies have been showed that Jujube could reduce DNA damage and ROS production in Caco-2 cells and could reduce inflammation via reduction of tumor necrosis factor 1, interlukine 1b, and 6. These Jujuba properties are related to its compositions ( Flavons, flavonoids, anthocyanins, polysaccharides, and phenolic acid). Jujuba's Polysaccharides, could reduce oxidative stress on colorectal cells and can be served as immune adjuvants to improve the immune responses. Polyphenols have antioxidant, anti-inflammatory, and anticancer properties. It was proposed that antioxidant activity of Jujube is related to the highest content of phenolics, flavonoids, and anthocyanins. Conclusion: In conclusion, Jujuba could be used for modulation and reduction of induced oxidative stress, inflammation and carcinogenicity by Lead in cancer and colorectal cancer, in combination with established treatments.