Functional Dyspepsia (FD) is among of the most common gastrointestinal diseases with an extraordinary burden. In this study, we aimed to compare the effect of Celery and Ajwain with Domperidone in patients with postprandial distress syndrome.

This is a randomized double-blind active-control clinical trial, piloted at Kerman, Iran in 2020. The intervention group received the combination of Celery and Ajwain while the control group received Domperidone for 4 uninterrupted weeks. Primary outcome was symptoms severity and frequency, and quality of life (QoL) and safety were secondary outcomes.

There were not any significant differences in symptoms frequency between groups, while differences in symptoms severity were available at the end of the follow-up on week 8 (P= 0.001). QoL in the treatment group was developed compared to the control group at the end of the study (P<0.001) and at the follow-up time (week 8; P<0.001). No health threatening side effects arose in both groups.

The herbal combination of Celery and Ajwain could be effective and safe in reducing the symptoms severity and in improving QoL in patients with postprandial distress syndrome type of FD. Endorsement of these findings through high-grade multi-center clinical trials is greatly recommended.