Background and Aims: Helicobacter pylori (H.pylori) is one of the common organism in human and it is a main agents to cause peptic ulcer and gastric cancer, H.pylori is a probable reasons of dyspepsia .The diagnosis of H. Pylori is based on two method’s: invasive such as endoscopy and biopsy and noninvasive methods such as unease breath test, serology and stool antigen test.This study aimed to investigation of Diagnostic value of H. pylori antibody test compared to stool H.pylori antigen test for detecting the active infection in patients with dyspepsia.

Materials and Methods: In an analytic cross sectional study with simple sampling method, the stool antigen and serology tests for Helicobacter pylori of all dyspeptic patients who referred to Khatamolanbia clinic were studied , and results of two tests were compared. All of the patients who were referred during 2015-2016 included and the patients who received antibiotics within last month or PPI during the last two weeks were excluded. The results were analyzed with chi-square test, kappa test, Fisher exact test, by SPSS ver17 software. Results: 340 cases were included; 212 patients were woman (62.4%) and 128 patients were man (37.6%) . Average age was 33.15±14.32 years. It shows that there is a significant relation between result of serology Ab test and stool Ag test (P value<0.005).sensitivity, specificity, PPV, NPV, accuracy respectively are:71.1%,68.4%,68.2%,71.3%,69.7%.

Results: 340 cases were included; 212 patients were woman (62.4%) and 128 patients were man (37.6%) . Average age was 33.15±14.32 years. It shows that there is a significant relation between result of serology Ab test and stool Ag test (P value<0.005).sensitivity, specificity, PPV, NPV, accuracy respectively are:71.1%,68.4%,68.2%,71.3%,69.7%.

Conclusion: Serology test has acceptable sensitivity and specificity in diagnosis of active H.pylori infection and it can be used as an alternative, noninvasive, inexpensive test.