Abstract Background: Statins have been used as adjuvants to the standard treatment in order to increase Helicobacter pylori eradication rates. The aim of this study was to summarize the results of the efficacy of adding statins to the standard treatment on H. pylori infection eradication. Methods: We conducted a systematic search using comprehensive combinations of keywords in PubMed/MEDLINE, Web of Science and Scopus to retrieve relevant studies from 1990 to 2020. The estimate of pooled relative risk (RR), as effect measure, was calculated using fixed and random effect meta-analyses in Stata 14. Results: The meta-analysis of data showed that pooled RR and its corresponding 95% confidence interval (CI) was 1.06 (95% CI 0.91-1.25) and 1.03 (95% CI 0.64-1.68) in fixed and random effect model, respectively, which are not statistically significant. In other words, based on our meta-analysis, the use of statins does not have a significant effect on increasing the H. pylori eradication rate. Conclusion: According to our findings, the addition of statins as an adjuvant therapy to the standard treatment regimen does not increase the rate of H. pylori eradication. However, further evidence is needed to confirm this result as the number of available studies is small.