: Cirrhosis is a progressive liver disease characterized by fibrosis and irreversible changes in the liver vessels. Due to the liver's vital role in metabolic functions, understanding the causes and complications of liver cirrhosis is crucial. A study was conducted on patients at Shohadaye Ashayer and Shahid Rahimi hospitals in Khorramabad from 2007-2017.

This descriptive-analytical cross-sectional study examined the frequency of cirrhosis causes and complications in patients at these medical centers during 2007-2017. Data including age, sex, causes of cirrhosis (alcohol consumption, history of hepatitis B , C , and D, autoimmune hepatitis, cryptogenic cirrhosis, primary sclerosing cholangitis, primary biliary cholangitis, hemochromatosis , and Wilson disease), and complications (ascites, edema, esophageal varices, hepatic encephalopathy, coagulopathy, splenomegaly, thrombocytopenia, and portal hypertension (HTN)) were collected from hospital archives and clinic records. The information was analyzed using Stata software version 16.

Results: The study involved 280 patients, with an average age of 51.02 ± 6.01 years. The majority of patients (23.3%) were in the 51-60 age group, and most were male (64.64%). The leading causes were history of hepatitis B (37.5%), cryptogenic cirrhosis (31.07%) , and history of hepatitis C (16.43%). Common complications included portal HTN (96.43%), thrombocytopenia (71.79%), and ascites (64.29%).

: The study revealed that a history of hepatitis B and cryptogenic hepatitis were the most prevalent causes, and portal HTN was the most common complication of liver cirrhosis across all ages and genders.