مقالات

Study of probiotic and simvastatin additive effect on helicobacter pylori eradication rate

1398/6/2 11:40
مقدمه

: Helicobacter Pylori (H. pylori) infection is a major cause of chronic gastritis, peptic, MALT lymphoma and gastric cancer. The eradication rate of Helicobacter pylori with standard treatments are decreasing worldwide. The aim of this study was to determine the efficacy of adding simvastatin or probiotic as adjuvant to quadruple therapy on the eradication of H. Pylori.

روش کار

This randomized clinical trial study was conducted on 160 patients with H. Pylori. The patients were randomly divided in to 4 groups. The group 1: standard quadruple eradication regimen consisting of two antibiotics (clarithromycin 500 mg and amoxicillin 1 g, all twice per day), a proton pump inhibitor (pantoprazole 40 mg twice daily), Bismuth (120 mg twice daily) with placebo (daily), group 2: standard regimen plus probiotic (daily east 250 mg), group 3: standard regimen supplemented with simvastatin (10 mg daily) and group 4: standard regimen plus simvastatin (20 mg daily) for 14 days was given. The Eradication was determined by Stool antigen tests (SATs) test at least 1 month after treatment.

نتایج

The eradication rate was 80% in placebo group, 77.5% in probiotic, 92.5% and 87.5% in simvastatin 10 mg and 20 mg groups respectively. Although eradication rates were higher with simvastatin than placebo and probiotic, but no significant differences were demonstrated between the 4 groups concerning eradication rate (P=0.229).

نتیجه‌گیری

Due to the high efficacy of simvastatin in H. pylori eradication, further studies are needed to evaluate the use of statins as adjunctive to improve the eradication rate.