Inflamation and gene regulations had a grand impact on developing and progression of Non-alcoholic fatty liver disease .The aim of present study is to investigate the signaling pathway based on NFKBand FOXP3 factors in patients with fatty liver disease cmpare to healthy subjects according to liver fibrosis.

Patients with fatty liver in ultrasonography evaluation who did not suffer from other liver problem,liver surgery , diabetis melitus , or using medications that has effects on liver function were enrolled . The eligible patients underwent liver fibroscan According to liver fibrosis the patients devided in two groups , whod had fibrosis less or more than 7.1 killo paskal . . Of them 5cc fasting blood samples were taken . the samples allocated in central lab of our center . The coagulum samples were centrifuged and the serum was removed and kept at -70 ºC. Then NFKB and FOXP3 levels were measured by using ELISA kits.

The results showed that the levels of NFKB and FOXP3 in patients non-alcoholic fatty liver with fibrosis greater than 7.1 were significantly increased (P-VALUE <0.05) compared to patients non-alcoholic fatty liver disease with fibrosis less than 7.1(p-value>0.05).

The present study showed that there is a direct relationship between NFKB and and FOXP3 and non-alcohol fatty liver disease progression.Therefore understanding the signaling pathways in this regard may help us to advancing investigations for NAFLD treatment.