Whether Helicobacter pylori triggers celiac disease (CD) or protects against CD is under question and need more research. There are epidemiologic studies that have reported conflicting results regarding the association between H. pylori and CD. increasing prevalence of CD disease had led to the consideration of a number of environmental risk factors that may trigger autoimmunity. Helicobacter pylori is one of the rare infectious agents (along with Epstein-Barr virus) that have been suggested to be involved in several autoimmune disorders.

This was a retrospective cross-sectional study of adult CD patients who were referred to the Mashhad Celiac Disease Center between 2015 and 2019 In 115 confirmed celiac patients who had positive serology and pathology in whom was evaluated helicobacter pylori by RUT at the time of first endoscopy included in our study . patients who had history of PPI use in last 2 weeks and antibiotic in last 4 weeks were excluded from study . prevalence of HP in 150 patients who had dyspepsia and gastric biopsy was done, was 75% which we except to be more common from GP without dyspepsia .Data was gathered and analyzing was done by SPSS

: in 115 patients who had RUT , 64 was positive (59%) and in 45 patients (39%) had negative HP and in 6 patient RUT was not done .

there was difference between HP in celiac disease and dyspeptic patients.