Sleep quality and disturbance recently considered as a important issue that significantly increases the risk of inflammatory diseases .In cancer patients this issue are multiply that may influence on general health of patients also adherence of them to therapeutic modalities. By the way studies on pancreatobiliary patients and sleep quality related factors remain unclear

In a prospective study, 471 patients diagnosed with pancreatobiliary cancers were included. Exclusion criteria consisted of no prior history of gastrointestinal cancer and no previous exposure to chemotherapy or radiotherapy. Each patient underwent an assessment involving a questionnaire covering demographic and anthropometric information, as well as sociodemographic details. Additionally, a set of checklists and questionnaires, including the Pittsburgh Sleep Quality Index (PSQI) and Health-related Quality of Life (HRQoL), along with laboratory data, were collected.

The average age of the participants was 62.5 years, with a standard deviation of 13.3 years, and the majority of them were male, accounting for 58.1% of the sample. Among these individuals, 322, or 65.5%, reported experiencing poor sleep quality. Notably, individuals with good sleep quality had significantly higher scores across all quality of life aspects. Good sleep quality was linked to notable improvements in both physical and mental aspects of quality of life. Notably, sociodemographic variables did not reveal any significant association with the sleep quality score. Among all quality-of-life subscales, sleep quality had the most significant impact on emotional and physical well-being, as well as mental health and bodily pain (p<0.001).

Among pancreatobiliary cancers sleep disturbance are common Issue that significantly effects on HQOL. Therefore, improvement and pay attention to patients emotional status and physical activity may improve sleep quality and also help the patient to better adapt to new condition.