Nigella sativa has been used in traditional medicine and several studies have been performed in the last decades to reveal the effects of it on different medical disorders such as diabetes, dyslipidemia, hypertension and obesity. To evaluate the effects of Nigella Sativa supplementation on Lipid profiles, glycemic control, blood pressure and some anthropometric indices in human.

A search on published studies is done by using the computer databases including pub-med, Google scholar, ISI (web of science) and Cochrane. MESH terms including: Nigella sativa, Black seed, Black cumin and kalonji. Initially 515 articles were extracted. 492 papers which were unrelated, review, animal studies, combined and duplicated studies were excluded, 23 articles were eligible for this review.

After analyzing 23 articles (Including 1531 participants) these results are achieved: In 4 trial Nigella sativa reduced blood pressure, however in 5 trial could not. Reduction in glycemic parameters in 13 studies were significant but in 3 studies were not. Although weight and waist circumference in 2 articles were reduced significantly, in 6 articles were not. Fluctuation in Lipid profile in the articles was very controversial so in many of them were significant but in others were not.

In this systematic review revealed that Nigella sativa supplementation was slightly effective in improvement of various clinical and biochemical parameters in humans.