Celiac disease is a common cause of malabsorption and this disease definitely diagnoised with abnormalities of narrow gastrointestinal biopsy and response to symptoms and histological changes of gluten removal. One of the serologic studies of celiac is Anti TTG study. Since IBS symptoms are common in the community and given the fact that the main food of the people of Gilan is rice and a number of patients with celiac are unknown and mistakenly diagnosed as IBS,a study was conducted to evaluate the prevalence of celiac disease in this group of patients (IBS).

In a cross-sectional study, 475 patients aged 20-70 years with IBS symptoms (according to ROME IV criteria) referred to Razi Hospital's Clinic of Rasht in the year 96 were selected.Blood samples were collected from all the patients. An upper endoscopy and Five samples of duodenal biopsy were collected from patients with positive serum sample. Statistical analyzes were performed.

In our study 475 people participated. (225 male and 250 female) The mean age of participants was 25.12±42.40. Anti TTG was positive in 31 patients (6.5%), Anti TTG IgA in 14 (2.9%) and Anti TTG IgG in 19 (4%) patients were positive. Of the patients with serum positive test, 6 cases had positive celiac disease in pathological endoscopy.

It is better to perform the required celiac examinations for all patients referring with IBS symptoms even those patients without Diarrhea and celiac symptoms. our study showed that the seroprevalence of celiac disease in patients with IBS symptoms is equal to 6.5 % and definitive diagnosis of this disease in seropositive people is 31.6 %.