Icter has always been seen as a tangible finding that can be a sign of major illnesses,. The aim of this study was to investigate the causes of jaundice in hospitalized adult patients from 2008 to 2018.

This study was a descriptive-analytical study that was done in a retrospective and cross-sectional method between 2008-2018 in Shahid Sadoughi Hospital of Yazd. All patients over 18 years of age who had bilirubin over 2.5 years were evaluated by referring to the hospital archive and HIS center and the required information including age, sex, liver enzymes and bilirubin levels were extracted and recorded. Finally, the data were analyzed by SPSS software

The results of this study showed that the mean age of patients was 56.44 years with the range of 19 to 93 years. . The average alkaline phosphatase was 1136.1. Total bilirubin and direct mean were 11.77 and 5.54, respectively. The most common diagnoses were bile duct stones, intra hepatic bile duct carcinoma and cirrhosis with 27.3%, 17.2% and 14.6%, respectively. The least common diseases admitted to the ward were hemolytic anemia, viral hepatitis, and hepatitis B. The results also showed a significant relationship between the causes of jaundice and age, sex, mean liver enzymes and bilirubin levels (p <0.05). At the age of 70 years, bile duct stones were the most common cause and at the age of aboe 70 years, intrahepatic bile duct carcinoma (25.5%) was the most common cause of jaundice. The most common cause of jaundice in men and women was bile duct stones with frequency of 30.8% and 24.3%, respectively. Most malignancies were more common in women.

The most common cause of jaundice in men and women was bile duct stones with frequency of 30.8% and 24.3%, respectively. Most malignancies were more common in women..