Fatty liver is going to be the first liver disease worldwide.The etiology of this situation remain unclear.Inflammation pathways may involved in its parthenogenesis.By the way immune modulators including FOXP3 and NFKB have strong influence in this way..

In a prospective study, the patients suspicious of having fatty liver without other pathology of liver or whom affected on liver performances were enrolled. The participantsunderwent liver fibroscan.According to liver fibrosis, the patients weredivided into two groups; 1)fibrosis less than 7.2 KP,2)advanced NAFLD, fibrosis ≥7.3 KP. A10cc fasting blood sample was taken from each patient for laboratory assessments.

Totally 90patients were enrolled.The mean age was 42.21±11 years. Of them, 50 and 47 participants were allocated to groups 1 and 2, respectively. there was a significant difference betweenthe levels of NFKB and FOXP3ingroup one comparedwith group two of the participants,as FOXP3(9.17±10.0 vs. 18.63±12.9;p<0.001) and NFKB (1.70± 1.70;p<0.01). After excluding the confounding factors, we observed a significant association between fibrosis level and cytokine levels in logistic regression.

Serum levels of NFKB and FOXP3 increased by advancing liver fibrosis in patients with NAFLD.This is an independent association.