Coeliac disease (CD) is a persistent autoimmune inflammatory condition affecting the digestive system and stands as a primary contributor to enduring malabsorption issues. Observations during endoscopy, such as scalloping and fissuring, have been documented to exhibit a comparable pattern with histopathological findings in CD. The objective of this study is to establish the relationship between endoscopic observations (scalloping, fissuring, or both) and histopathological results in CD patients aged 60 years and above

This observational research was carried out on 41 CD patients ≥ 60 years . Individuals displaying symptoms suggestive of CD underwent serology assessments and upper gastrointestinal endoscopy accompanied by duodenal biopsy. The severity of intestinal injury was assessed utilizing the Marsh-Oberhuber classification system, which relies on histopathological observations

Overall, 80.5% of the patients were female and the mean age of the patients at diagnosis was 65.68±4.38 years with mean body mass index (BMI) of 24.39±5.31. Out of 41 patients, 30 (90.9%) of the patients who displayed scalloping, fissuring, or both were categorized as Marsh 3. Across the entire patient cohort, the sensitivity, specificity, positive predictive value, and negative predictive value of endoscopic observations regarding the histological identification of CD were 81.08%, 25%, 90.91%, and 12.5%, respectively. The positive likelihood ratio was 1.08, and the negative likelihood ratio was 0.76.

: Further evaluations are required for establishing the relationship between endoscopic findings such as scalloping, fissuring, or both and histopathological results in CD adult patients over 60 years.