Early diagnosis of colorectal cancer is the best way to reduce its mortality. The purpose of this study was to determine the diagnostic value of M2PK and FIT findings in comparison with colonoscopy findings in patients referred to Caspian Gastroenterology Clinic.

In a study evaluating diagnostic tests, demographic and clinical characteristics (age, gender, BMI, history of smoking, alcohol, underlying disease, gastrointestinal symptoms) were obtained from all subjects referring to colonoscopy, as well as from all subjects Fecal samples were taken for evaluation of M2PK and FIT levels. M2PK was evaluated by ELISA with ScheBo kit and FIT was performed immunologically with device or tablet. Then the three tests were compared in terms of sensitivity, specificity and positive and negative predictive values.

The results also showed that the sensitivity of M2PK test for colonoscopy findings was 78.6% and the specificity of this test was 87.1% and the sensitivity of FIT test was 67.1% for colonoscopy findings and the specificity of this test was 1.1. 37% were reported. There were no statistically significant differences between the two M2PK and FIT tests with colonoscopy for demographic and clinical characteristics and histologic findings.

Considering that nowadays invasive tests like M2PK which are cheaper than colonoscopy can be used in the first stage of screening and this can be a great step in screening individuals and identifying pre-cancerous lesions and As a result, there is a reduction in colorectal cancer and a decrease in death from this cancer.