In this study, along with the determination of colorectal adenoma profile, we try to address whether young and female patients remain low-risk groups for colorectal adenoma.

In a retrospective investigation, the medical records of 15,420 patients who had undergone total colonoscopies for various reasons and had been referred to a Tertiary Hospital in Tehran, Iran, were meticulously examined. The collected data included demographic information and details regarding the lesions, sourced from both endoscopic and pathologic reports.

The analysis encompassed the records of 15,420 patients, revealing the presence of polypoid lesions in 4,542 individuals, constituting 29.5% of the studied population. The average age of the patients was 57 years, with a standard deviation of 14.4 years, and the majority, accounting for 61.3%, were male. Among these patients, 3,494 (77.5%) had adenomas, with 1,912 (54.7%) classified as advanced adenomas, 148 (4.2%) as serrated adenomas, and 298 (8.5%) as malignant polyps. Histopathologically, the most common adenoma type was tubular, primarily located in the distal colon. The prevalence of adenomas did not significantly differ between genders. However, significant associations were observed between gender and the number of lesions concerning the type of adenoma, while lesion size exhibited significant associations with malignancy development.

these findings indicate that age and gender may not exert the same level of influence on the development of colorectal Neoplasia and consequently cancer (CRC) as previously believed. Consequently, there is a need to reconsider the threshold for colonoscopy and establish a screening program for this region that takes into account factors beyond age and gender.