Crohn’s disease is an inflammatory gastrointestinal disease that has many extra-intestinal involvements. Abdominal abscess is a rare manifestation of Crohn’s disease. It has many etiologies that have been deliberated. The keywords were searched in the valid database and the articles that were most related to the purpose of the study were discussed. The aim of this article is to review the effect of anti-TNF, on Abdominal abscesses in Crohn's patients. Anti-TNF-α plays a challenging role; it may be the cause of the abscess, and on the other hand, it’s the main treatment of Crohn’s disease.