Ulcerative colitis (UC) is a common type of inflammatory bowel disease (IBD) with increasing prevalence over time1. It is characterized by periods of active disease and remission.the MIND diet highlights the consumption of natural plant-based foods and limits the intake of animal and high saturated fat foods. This pattern is unique in recommending the consumption of berries and green leafy vegetables21. These food items are good sources of different phenolic compounds, fibers, and antioxidant vitamins and minerals.

The present cross-sectional study was conducted in the IBD clinic of Imam Reza Hospital, the central clinic of IBD management in East Azerbaijan, Iran. One hundred fifty-eight patients with UC were enrolled from July 2022 to March 2023. The inclusion criteria for participation in the present study were age 20–60 years old and being diagnosed at least six months before contribution. The exclusion criteria were having other gastrointestinal problems, tumors, autoimmune diseases, or other disorders that necessitate following special diets. Demographic information, including age (continuous), sex (male/female), and smoking status (current smoker) was obtained using a demographic questionnaire by in-person interview. the disease severity was determined by a skilled gastroenterologist and endoscopist using the Mayo score. This score. A valid 168-item Food Frequency Questionnaire (FFQ)32 was applied to gather the dietary intake of different food items in the past year and completed by a skilled nutritionist

after adjusting for diet-related, and demographic characteristics, compared with the patients in the first tertile of the MIND diet score, the patients in the third tertile had significantly lower odds of disease severity (OR: 0.39, 95% CI: 0.16, 0.97).

In conclusion, the results of the present study showed that high adherence to the MIND diet score was significantly associated with lower odds of severe UC.