Introduction: According to Rome IV criteria, irritable bowel syndrome (IBS) is the most common functional bowel disorder with recurrent abdominal pain associating with defecation or a change in bowel habit. IBS is a multifactorial disorder relating to genetics, stressful life events, increased mucosal permeability, visceral hypersensitivity, altered smooth muscle contractility, and immune Dysfunction. Several studies reported the efficacy of herbal remedies in improving IBS symptoms. Thereupon, we decided to review Persian herbal medicine in IBS. Material & methods: We searched on electronic databases including Pubmed, Scopus, Cochrain, Embase, Science direct, Web of science and SID with the aim to find clinical articles related to IBS and herbal medicine since 2019. We used such keywords as traditional medicine, complementary and alternative medicine (CAM), herb, plant and IBS. Non-randomized clinica l trial, non-relevant studies, supplement, vitamins, pre or probiotics and none Persian herbal drugs were excluded. Results: Finally, we found 23 randomized control trial with 9 simple Persian herbal medicine and 6 compound formulation that potentially improve IBS symptoms without remarkable adverse effect. Mentha piperita (Nana), Pimpinella anisum (Anisun), Curcuma longa (Zardchoobeh), Glycyrrhiza glabra (Shirinbayan), Zataria multiflora (Avishan), Gingiber officinalis (Zanjabil), Artichoke (Kangar), Plantago psyllium (Psyllium), Hypericum Perforatum (Alaf e chy), Mentha longifolia, Cyperus rotundus and Zingiber officinale (Nana, Sod, Zanjabil), Curcuma longa and Foeniculum vulgare (Zardchoobeh, Razianeh), Boswellia carterii, Zingiber officinale, and Achillea millefolium (Kondor, Zanjabli, Bumadaran), Melissa officinalis, Mentha spicata, and Coriandrum sativum (Badranjbuyeh, Nana, Geshniz), Murraya koengi, Punica granatum, Curcuma longa (Kari, Zardchoobeh, Anar), Aloe vera, Curcuma longa, Peppermint oil, Ulmus kub (Aloe vera, Nana, Narvan, Zardchoobeh). Conclusion: Herbal remedies are acting with controlling abdominal pain, anti-inflammatory activity, and enhancing and coordinating the gastrointestinal motility. Although their mechanisms are not fully understood, they can be recommended as a complementary therapy to alleviate IBS symptoms.