Inflammatory bowel disease (IBD) is a multifactorial inflammatory disease that contains Crohn’s disease (CD) and ulcerative colitis (UC). Incidence and prevalence of IBD are increasing geographically around the world. Long noncoding RNAs (lncRNAs) were recently identified to have a key role in regulating biological functions in human disease. Although the exact role of lncRNAs in IBD remains unknown, it is determined that the expression of some lncRNAs is changeable in IBD.We aimed to evaluate the expression of CRNDE lncRNA in patients with IBD CD and UC.

In this study, CRNDE lncRNA in intestinal blood and tissue samples were detected by quantitative real-time PCR. We performed this test in 53 patients including 20 people with ulcerative colitis (UC), 13 people with Crohn's disease (CD) and 20 normal people as the control.

In this study, we identified a widespread dysregulation of lncRNA in both CD and UC patients compared to the normal controls. We found that lncRNA CRNDE expression was elevated in IBD patients. This upregulated of CRNDE lncRNA was different in UC and CD patients, UC patients showed significantly a higher expression of CRNDE in compared CD patients.

Our data present that lncRNA CRNDE is involved in inflammatory bowel disease patients, which provide a potential prognostic biomarker and therapeutic targets.