Aim: To conduct a comprehensive analysis of the existing literature regarding the potential correlation between alcohol consumption and colorectal cancer (CRC) within the Eastern Mediterranean Regional Office (EMRO) region. Material and Methods: Two researchers independently conducted separate searches on PubMed, Scopus, and Web of Science. The quality of the included studies was assessed using the Newcastle-Ottawa (NCO) checklist. To evaluate heterogeneity, the Cochrane test and I2 statistics were employed. Additionally, meta-regression analysis was utilized to investigate the influence of study sample sizes and the Human Development Index (HDI) on the combined effect. Results: Finally, eleven articles meeting our inclusion criteria were selected for analysis. Our meta-analysis unveiled a noteworthy positive correlation between alcohol consumption and the risk of CRC (Odds Ratio [OR] = 1.51; 95% Confidence Interval [CI]: 1.03-2.22; p = 0.03). The meta-regression analysis results indicated that neither the sample sizes of the studies (p = 0.85) nor the HDI of the countries (p = 0.07) had a significant impact on the overall effect. Conclusion: Individuals who engage in high or low levels of alcohol consumption and may be at risk for CRC would benefit from being informed about the potential positive correlation between these factors within the EMRO region. By promoting early diagnosis, implementing effective screening techniques, and providing state-of-the-art treatment procedures, it is possible to reduce CRC mortality rates and enhance survival rates among residents of the EMRO region.