Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver condition recently. The objective of this study was to investigate the potential link between dietary advanced glycation end products (AGEs) and MASLD in patients with diabetes (T2DM).

Two hundred patients with T2DM participated in this cross-sectional study, including 133 patients with MASLD and 67 patients without MASLD. Fibroscan was used to measure hepatic steatosis. A validated food frequency questionnaire was employed to ascertain the dietary intake of individuals, and we utilized multiple logistic regression to examine odds ratios (ORs) and 95% confidence intervals for MASLD according to quartiles of dietary AGEs.

Participants exhibited higher AGE intake as fat mass and CAP score increased (P= 0.016 and P= 0.011, respectively). The risk of MASLD was significantly greater in the highest quartile of dietary AGE levels than in the lowest quartile, and this link became more powerful when additional adjustments for possible confounders were made. An OR of 5.14 (95% CI = 1.34- 19.6) with a significant trend (P-trend = 0.008) was found after complete adjustment for possible confounders (age, sex, smoking status, physical activity, duration of diabetes, fasting blood sugar, serum triglyceride, serum total cholesterol, energy intake, and BMI).

Our results revealed that high dietary AGE levels were linked to an elevated chance of MASLD in diabetic patients. Multicenter investigations with larger sample sizes are warranted to validate these findings.