NAFLD (Non Alcoholic Fatty Liver Disease) is the most common cause of chronic liver injury in many countries around the world. Approximately a third of populations are affected by NAFLD. Although liver biopsy is the gold standard method for diagnosing and staging NAFLD, the majority of patients can be effectively diagnosed noninvasively with tests that are routinely are available in clinic today.

255 cases with metabolic syndrome who denied history of alcohol consumption were enrolled in this study; which 63 of them had NAFLD by liver sonography. Demographic data were collected. Weight, height, FBS, 2HPP, AST, ALT, WBC (diff), Platelet count, Albumin and Ferritin were measured. Non invasive score for fibrosis such as AAR, APRI, BRAD, FIB-4 and NFS score were calculated for all participants. Descriptive and analytical statistics were assessed by SPSS version 23. Independent sample T-test and ANOVAwere used for analytical evaluation.

Mean value of AAR, APRI, FIB-4, BRAD and NFS score in NAFLDs were 0.74±0.41, 0.32±0.14, 55.25±35.37, 3.16±0.77 and -1.34±1.26 (Mean±SD) respectively with significant differences between theses markers in NAFLDs and non NAFLDs (PV=0.0001, 0.0001, 0.0001 and 0.0001) except NFS (PV= 0.964). Also between NAFLD patients with different grades of fatty deposition on sonography AAR, APRI, FIB-4 and BRAD score were statistically significant (PV=0.001, 0.0001, 0.0001 and 0.002) but NFS score had no significant differences (PV=0.251). Alghough lymphocyte had significant differences between two groups and different grades of fatty deposition (PV=0.045 and 0.013) but Ferritin differences between NAFLDs and non NAFLDs and different grades of fatty deposition were not significant (PV=0.322 and 0.581).

Non invasive parameters is relevant to fatty deposition on sonography in non alcoholic fatty liver diseases and combination of them can use for selection patients for more evaluation such as liver biopsy or ultrasound elastography (FibroScan).