Colorectal cancer is among the most important cause of death worldwide. It is widely accepted that most of CRC are arise from colorectal polyps. In recent years there is a specific rise in incidence of adenomatous polyps in Iran. Unlike high prevalence of colorectal cancer in east and north-east of Iran; unfortunately, there is no obvious demographic data of colorectal polyps in this region. In current paper we aimed to measure histological and clinical characteristics of colorectal polyps in east and north east of Iran.

This study is a cross sectional retrospective review of documented polypectomies and polyp biopsies that were assessed by three referral pathology clinic in Mashhad, Iran between 2012 and 2017.

A total of 738 patients regarding sex 405 (54.9 %) were male. The mean age of our patients was 54.61±14.52. adenomatous polyps were the most common pathological finding (n = 552,74.8 %), hyperplastic polyps were 93(12.6%) and serrated polyps were 18(2.4%). Adenomatous polyps were documented as below: tubular type (391,53%), tubulovillous (144,19.5%) and Villous (17,2. 3%). of 738 polyps, the exact location of 661 polyps were specified and within 661 polyps 520(78.7%) were in distal colon. The mean age of patients with adenomatous polyps was 56.37±13.81, and 184(25.4%) were under age 50. among adenomatous polyps 152(20.6%)were detected with high grade dysplasia. advance polyps were diagnosed in 234(31.7%) and they mostly located in distal colon (82.4%)

Distal colon was site of most of the polyps. The measurement of advance polyps is increased. This high prevalence of advance polyps in our patients implies the urgent need for screening plans to prevent colorectal cancer in our region.