Introduction: In the present study, the effectiveness of Sovodak, which is a combination of the above two drugs in one tablet, in the treatment of patients with chronic hepatitis C and cirrhosis was investigated.

Material and Method: Patients with chronic hepatitis C whose disease was confirmed by HCV RNA-PCR test were included in the study. These patients received one Sovodak tablet daily (for 12 weeks for non-cirrhotic patients and 24 weeks for cirrhotic patients). Sustained virologic response (SVR) was assessed by PCR test 12 weeks after the end of the treatment and one year later. Also, serum levels of liver enzymes, platelet count, and liver stiffness (using elastography method) were measured and their levels were compared before and after treatment in patients.

Results: Findings related to the PCR test in patients showed that the level of sustained virologic response was 100% in 12 weeks after treatment (SVR-12) in the patients. In 3 cirrhotic patients who received only 12 weeks of drug treatment, the disease recurred a year later. According to the results, ALT and AST serum levels were significantly decreased (P<0.001), and platelet count level was increased (P<0.001) one year after the end of the treatment period. Also, the liver stiffness index measured using Fibroscan was significantly decreased in patients 12 weeks after the end of treatment (P<0.001).

Conclusion: The results of this study, in confirmation of other studies, showed the effective role of Sovodak in eliminating the HCV virus in patients with chronic hepatitis C to 100%. Cirrhotic patients need to receive treatment for at least six months.