Introduction: Gastrointestinal problems caused by coronavirus infection, identification of clinical changes and gastrointestinal enzymes and gastrointestinal symptoms in patients and knowing how to change them, control and compensate for these changes to normal In patients, it is important and attention. Therefore, this study was designed with regard to different symptoms of coronavirus and gastrointestinal changes in patients with the aim of investigating clinical changes, laboratory indicators and gastrointestinal symptoms in patients with coronavirus.

Methods: This study was performed based on patient records in the archives of Velayat hospital, Qazvin. The records of all patients with gastrointestinal problems with coronavirus, which were confirmed by CT scan and Real time PCR, it was studied from February 2020 to August 2020. SPSS software version 23 was used for data analysis. Analysis of variance (ANOVA), paired samples t-test and Chi-square were used for statistical analysis (P <0.05).

Results: During the study period, 160 patients with coronavirus infection who also had gastrointestinal and hepatic disorders were randomly evaluated. Most patients were between the ages of 30 years <. Clinical changes were directly related to changes in alanine aminotransferase, alkaline phosphatase, bilirubin, amylase and lipase (P <0.05). Also, physical symptoms in all patients with coronavirus infection and gastrointestinal disorders included vomiting, nausea, diarrhea, and abdominal pain (P <0.05).

Conclusion: In the present study, the symptoms and clinical changes were the same in all patients with coronavirus infection who were simultaneously with gastrointestinal and hepatic disorders. Therefore, the presence of gastrointestinal and hepatic symptoms and changes in laboratory parameters can be used as a prognosis in identifying people with coronavirus. Keywords: Clinical Changes, Liver Enzymes, Gastrointestinal Symptoms, Coronavirus