Liver diseases lead to the approximately 2 million deaths per year worldwide. Liver injury, indicated by elevated blood alanine aminotransferase (ALT), aspartate transaminase (AST), or gamma-glutamyl transferase (GGT) levels. The serum uric acid (SUA) level has been suggested to be associated with metabolic syndrome and other chronic diseases. However, little is known about the relationship between SUA and liver enzymes levels in the general population. Therefore, we intend to study the correlation between SUA and liver enzymes among healthcare workers in the Azar Cohort Study.

This cross-sectional study was conducted on 1,458 healthcare workers in the Azar cohort population. Blood samples were obtained from the participants to determine the serum levels of ALT, AST, GGT, alkaline phosphatase (ALP), and SUA of participants. The participants were categorized into three tertiles based on SUA levels, Tertile 1: 2–4 mg/dl; Tertile 2: 4.1–5.1 mg/dl; and Tertile 3: 5.2–10 mg/dl. The correlation between SUA and liver enzymes was determined by Pearson-test.

The serum levels of ALT, AST, GGT, and ALP were significantly higher in the third tertile of the SUA levels than the first two tertiles (all p<0.001). Moreover, we observed an ascending trend in the mean values of liver enzymes from the first SUA tertile to the third SUA tertile (p < 0.05). There is significant correlation between SUA and liver enzymes levels (P<0.05).

The finding demonstrated a significant relationship between the SUA and the liver enzymes. We suggest the use of the SUA levels for early diagnosis of the liver diseases. More prospective studies are needed to clarify the complex association between SUA and liver enzymes in the general population.