Gastrointestinal bleeding is one of the most common causes of hospitalization. In this study, we investigated the mineral-herbal solution's effectiveness in controlling the upper GI tract's visible non-bleeding vessels (NBVV).

In this randomized controlled study, 101 patients with upper gastrointestinal bleeding, who were referred to the emergency department of Ghaem and Imam Reza hospitals in Mashhad city, were enrolled. All patients were randomly divided into three groups include; a) treatment with Hemostasis Powder® (n=34), b) treatment with argon plasma coagulation (APC) plus epinephrine injection (n=35), and c) treatment with Hemoclips plus epinephrine injection (n=32). After primary endoscopic treatment, 24 hours later, the patients underwent re-endoscopy, and during hospitalization, all clinical and laboratory findings were recorded.

In patients who underwent treatment with Hemostasis Powder®, the bleeding complication during the initial treatment was significantly lower than in the other two groups (P=0.02). Patients treated with Hemostasis Powder® did not need secondary interventions, while 20% and 10% in the APC and Hemoclips groups, respectively (P=0.02). Moreover, no statistically significant difference regarding mortality incidence was found between the three groups (P=0.15).

These findings show that Hemostasis Powder® can consider a suitable therapeutic option for the NBVV of the upper GI tract.