Liver cirrhosis (LC), the end-stage phase of any untreated chronic liver disease (CLD), can progress to hepatic decompensation, hepatocellular carcinoma (HCC) and eventually death. Globally there are more than 1 million and 500,000 deaths due to cirrhosis and HCC respectively per year worldwide. In Iran, 4500 deaths were reported due to cirrhosis in 2017, which comprises 2.6% of all deaths, and, importantly, 20 percent were below age fifty. Although viral hepatitis B have been the most important cause of LC, but non-alcoholic fatty liver disease (NAFLD) has been raised as the main cause of chronic liver disease in recent years. The main causes of death have been liver-related complications, but a significant component of deaths have been due to non-liver causes such as CVD, malignancies, and infection, especially in NAFLD. With recent advances, especially in non-invasive measures, the natural history of LC has been more clearly defined, and now the LC is not a single entity, so it can be divided into compensated and decompensated phases, and in more detail, and in more detail, can be divided into at least four to five stages with different presentations and outcomes. Importantly, for the implementation of any standard or quality definition, this categorization can help us better define the quality of care and set standards of care at each stage. Some factors, such as education and empowerment, self-involvement in the health care team, familial and social support, access to health care facilities, insurance quality, stress management, regular exercise, and healthy nutrition, can improve both the quality of care and also the quality of life which have reciprocal effects, but the quality of care is our main point in this article. The quality of care is not related to liver disease per se. Management of comorbid conditions such as cardiovascular disease, diabetes mellitus, malignancies, and infections has an important effect quality of care for these patients. The liver-related quality of care can also be fractionated into different stages of chronic liver disease. Early diagnosis in high-risk groups, cost-effective use of diagnostic methods, etiologic diagnosis and suitable management, a cost-effective screening program for esophageal varices and hepatocellular carcinoma, early diagnosis and management of decompensation and complications of cirrhosis, and timely allocation for liver transplantation, are important components of improving quality of care. Although there are important gaps between daily clinical practice and regional and accepted standards, determining standards of care can improve this condition and fill these gaps. There are multiple studies which reveals setting standard of care such as use of the chronic disease management paradigm, the day hospital setting, and the checklist in hospitalized patients improved the quality of care in these patients. It is assumed that the area of quality of care in different aspects of diagnosis, management, and outcome measures in chronic liver disease has been improved basically, but needs more studies for their cost-effective implementation in daily clinical practice.