Non-alcoholic fatty liver disease (NAFLD) is a serious liver disease which convert to a challenge for health system. the present study aimed to investigate the epidemiological, clinical and laboratory findings of NAFLD in Khorramabad city.

In this cross-sectional study, Patients referred to the gastroenterology clinic of Shahid Rahimi Hospital in Khorramabad city were selected by convenience sampling method .the study population was selected among patients with confirmed NAFLD by ultrasound. Demographic information, body mass index, ultrasound of NAFLD grades and biochemical parameters (FBS, cholesterol, triglyceride, LDL, HDL, ALT and AST) were assessed in this study.

286 patients with NAFLD were included in this study. The mean age of patients was 49.1±12.3 years. 158 patients (55.2%) were male and the rest were female. BMI of the majority of the subjects means 140 patients (49%) was between 25 and 29.9, i.e. were placed in overweight range, 56 patients (19.5%) had a BMI of ≥30 (had obesity) and BMI was normal in 90 patients (31.5%). The majority of patients (73.8%) had grade 1 (mild) fatty liver, 21.7% had grade 2 (moderate) fatty liver and 4.5% had grade 3 (severe) fatty liver. In 27.5% of patients, the level of total cholesterol was ≥240 mg/dl. Also, in 55.3% of patients, the level of triglyceride was ≥200 mg/dl. In 19.5% of patients, the level of LDL cholesterol was ≥160 mg/dl. HDL cholesterol level was below 40 mg/dl in 44.9% of men and below 50 mg/dl in 53.1% of women. Finally, based on the measurement of fasting blood sugar, 30.4% of the patients were pre-diabetic and 40.2% were diabetic

In general, it can be concluded that risk factors related to metabolic syndrome play a crucial role in the development of NAFLD.