بایگانی مقالات

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خلاصه مقالات نوزدهمین کنگره گوارش و کبد ایران
Evaluation of invasion and migration ability of HCC model ( SK-Hep-1) after treatment with linoleic acid as a natural ligand of HNF4α
1.7 بیولوژی سلولی و مولکولی - فیبروز
Zohreh Miri Lavasani, Ensieh Zahmatkesh, Zahra Farzaneh, Abbas Piryaei, Massoud Vosough, Azadeh Haeri

Background: Nowadays considering the growing number of liver neoplasia and lack of failure in effective treatment, , differentiation therapy is considered as a promising strategy for inhibition of recurrence. Numerous efforts have been made to promote differentiation in cancerous cells. HNF4a as a curtail transcription factor in hepatocytes, emerge to be a kay conductor in differentiation by mediating EMT-MET process. Enhancement of HNF4a expression appeared to decrease invasion in carcinoma cells by suppressing Snail and decreasing EMT markers. Conjugated Linoleic acid (CLA) is an essential fatty acid has been identified as a potential anti-obesogenic and anti-carcinogenic agent. It is also known as a natural ligand of HNF4a

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خلاصه مقالات نوزدهمین کنگره گوارش و کبد ایران
A Novel LIPA Mutation Found Using Exome Sequencing in Siblings with NAFLD/NASH
3.7 متابولیک / اختلالات ژنتیکی
امیر انوشیروانی, رضا ملک زاده, آریا مانی

During the last 2 decades, an epidemiologic transition has happened across the world, which is especially noticeable in developing countries, and has resulted in an obvious shift from communicable infectious diseases to chronic non-communicable diseases .Little is known about the heritability of hepatic fibrosis, and the heritability of hepatic steatosis has not been assessed systematically in adults. Recent studies have suggested that there is a significant genetic association with the presence of hepatic steatosis. Lysosomal acid lipase (LAL) deficiency is a rare autosomal lysosomal storage disease. We described a novel mutation in the LIPA gene where the proband had liver cirrhosis without even noticing any symptoms, presenting only with low platelet counts

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خلاصه مقالات نوزدهمین کنگره گوارش و کبد ایران
Mucoid-coccoid H. pylori and antibiotic resistance
3 هلیکوباکتر پیلوری
Farideh Siavoshi, Sara Kadkhodaei

: In this study one H. pylori isolate from gastric biopsy of a dyspeptic patient that turned into mucoid-coccoid (MC) form upon consecutive subcultures, was identified. The culturability, antibiotic resistance and lipid contents of MC were compared with those of non-mucoid (NM) spiral H. pylori

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