The Combination of Sofosbuvir and Daclatasvir is Well Tolerated and Extremely Effective in Treating Patients with Hepatitis C with Severe Renal Impairment Including Hemodialysis Patients
1.1 اپیدمیولوژیMany of the treatments available for hepatitis C include sofosbuvir. Unfortunately sofosbuvir has not been cleared for use in patients with eGFR under 30 ml/min/1.73m2 leaving these group of patients with few options. Nevertheless, there are many reports in which patients with renal failure have been treated with sofosbuvir-containing regiments without any important adverse events
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Opium Use And Risk Of Stroke Mortality Within The Golestan Cohort Study (GCS)
1.1 اپیدمیولوژیCardiovascular diseases including stroke are of increasing concern as the leading cause of mortality in low-middle income countries. Opium addiction is an independent risk factor for Ischemic stroke. The main objective of this study is to evaluate associations between opium use and risk of stroke mortality in the GCS
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Circulating Cell-free DNA in archived low quality volume serum samples: Rate of concordance with mutation in tumor
1.1 اپیدمیولوژیCell-free DNA (cfDNA) is considered as non-invasive method for cancer detection with high specificity and variable sensitivity. Mainstream cfDNA studies are based on qualified samples which is plasma kept at -80, with no cycle of re-thawing, and minimum volume of 1 ml. We aim to investigate feasibility of cfDNA detection in archival serum samples kept at -20 with several cycles of re-thawing and volume less than or equal to 0.7 ml.
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